Informatics Publishing Limited

A. Narayana Rao ¹, Ch. D. V. Subba Rao ²

Affiliations
1 CSE Dept at Shree Institute of technical Education, Tirupathi, IN
2 Computer Science and Engineering Department, at College of Engineering, Sri Venkateswara University, Tirupathi, IN

Abstract

The paper deals with the Quality of Service (QOS) issues in Wireless Mesh Networks. Several real time implementations of Wireless Mesh Networks have been taken in to account and QOS of all are analyzed and validated for its quality. When compared to other traditional computer networks WMN, lacks quality, in terms of performance. The best way to improve the quality of service is to analyze and review each of the components that aid the working of wireless mesh networks. The paper also presents certain solutions and suggestion for improving the quality. In implementation of WMNs factors like delay, capacity, coverage and design principles of routing protocols that plays a vital role in the working of WMN are taken in to account. Each of the above factors has a trade-off and which influences the overall working of the WMN. For improving performance of QOS, traffic also to be taken into consideration. This paper influences the ways to develop algorithms for sustaining QOS. Therefore the present survey is essential to tackle the challenge of enabling QOS in WMNs.

Keywords

Wireless Mesh Networks, QOS, Performance and Quality.

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A. Anka Rao ¹, K. Pavan Kumar ², A. Narayana Rao ¹, Narender Malothu ¹, B. Prassana Kumar Desu ¹, Naga Raju Bandaru ¹

Affiliations
1 K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh - 522 502., IN
2 Research Scholar, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh-522 502., IN

Abstract

Objective: Highly responsive simple Liquid-liquid Extraction Glipizide development using deuterated Glipizide and Sitagliptin LC-MS/MS Glipizide for gradation of Glipizide and Sitagliptin in rat plasma Glipizide: The chromatographic condition involves, isocratic mode using waters X-Bridge C18 3.5μ (150x4.6mm) column. Mobile phase 0.1% orthophosphoric acid and Acetonitrile in the ratio (80:20) was used and detection was carried out in a positive mode of electrospray ionization by using MS. Results: Glipizide has been validated, the linearity was observed in the range 10-150 ng/ml and 0.1-1.5 ng/ml for Glipizide and Sitagliptin respectively. For intraday and inter-day precision %RSD values were found to be within the acceptable limits. Recovery studies for Glipizide and Sitagliptin obtained was 99.5% and 98.6% respectively. The battery of stability studies like bench-top, Autosampler stability, freeze-thaw, and long term stability was performed. Conclusion: Highly responsive simple liquid chromatography tandem mass spectroscopy assay Glipizidewas developed and witnessed for the gradation of Glipizideand Sitagliptin in rat plasma, the developed Glipizidewas applied to pharmacokinetic studies.

Keywords

LCMS, Glipizide, Sitagliptin, Glipizidevalidation, pharmacokinetic study.

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Nagaraju Bandaru ¹, A. Narayana Rao ¹, Yasho Deepika ², Alekhya Ketha ³, Daveedu Thathipudi ⁴, N. Sri Laxmi ¹

Affiliations
1 College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram, Guntur - 522502, Andhra Pradesh, IN
2 Department of Pharmacy, Anurag University, Venkatapur, Ghatkesar, Hyderabad - 500088, Telangana, IN
3 Bharat Institute of Technology-Pharmacy, Mangalpally, Hyderabad - 501510, Telangana, IN
4 Department of Biotechnology, Vikarma Simhapuri University, Nellore – 524320, Andhra Pradesh, IN

Abstract

The Fraction from Methanolic extract whole plant of Biophytum reinwardtii (HEMBR) is traditionally used in the treatment of diabetes. Rats were treated with a standardized dose of Dexamethasone for 14 days and the effect of HEMBR at the doses of 50 and 100 mg/kg, p.o. on plasma blood glucose level, serum triglyceride level, glucose uptake in skeletal muscle, levels of hepatic antioxidant enzymes (GSH, SOD and catalase), and body weight were observed. HEMBR showed a significant decrease in plasma glucose and serum triglyceride levels (p < 0.01) at the dose of 50 and 100 mg/kg, p.o. and also stimulated glucose uptake in skeletal muscle. The levels of antioxidant enzymes, GSH, SOD, and catalase were significantly increased (p < 0.01). Hence it can be concluded that Biophytum reinwardtii may prove to be effective in the treatment of Type-II Diabetes mellitus owing to its ability to decrease insulin resistance.

Keywords

Antioxidants, Diabetes, Fraction, Insulin, Resistance

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